How Scale-Free Are Biological Networks
نویسندگان
چکیده
منابع مشابه
How Scale-Free Are Biological Networks
The concept of scale-free network has emerged as a powerful unifying paradigm in the study of complex systems in biology and in physical and social studies. Metabolic, protein, and gene interaction networks have been reported to exhibit scale-free behavior based on the analysis of the distribution of the number of connections of the network nodes. Here we study 10 published datasets of various ...
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We study the diameter, or the mean distance between sites, in a scale-free network, having N sites and degree distribution p(k) proportional, variant k(-lambda), i.e., the probability of having k links outgoing from a site. In contrast to the diameter of regular random networks or small-world networks, which is known to be d approximately ln(N, we show, using analytical arguments, that scale-fr...
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A central claim in modern network science is that real-world networks are typically “scale free,” meaning that the fraction of nodes with degree k follows a power law, decaying like k−α, often with 2 < α < 3. However, empirical evidence for this belief derives from a relatively small number of real-world networks. We test the universality of scale-free structure by applying state-of-the-art sta...
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This paper reexamines the claim that biological networks are robust due to their scale-free (SF) architecture, by presenting a basic and simple way to assess the role that this architecture plays in determining network robustness. Studying the error tolerance of the yeast protein-protein interaction network [7] to random node removal using the pertaining knockout data we show that it is only ve...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2006
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2006.13.810